• Profile picture of Alice Adriaenssens
    Role: Post Doctoral
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories, MRC Metabolic Diseases Unit
    Research Summary:
    Department of Clinical Biochemistry, Metabolic Research Laboratories, MRC Metabolic Diseases Unit
  • Profile picture of Matthew Banton
    Role: Post Doctoral
    Affiliation(s): Metabolic Research Laboratories
    Research Summary:
    I am a postdoctoral research associate in the laboratory of Professor Sadaf Farooqi. I am studying the roles that novel mutations have on individuals with early onset obesity. I use molecular, biochemical and microscopy techniques to functionally cha... Read more
  • Profile picture of Inês Barroso
    Role: Principal Investigator
    Affiliation(s): Metabolic Research Laboratories, Wellcome Trust Sanger Institute
    Research Summary:
    We have been using genome-wide association and sequencing approaches to identify genes with a role in obesity, type 2 diabetes and related quantitative traits, as well as rare extreme forms of these diseases. More recently, we have also focused on ex... Read more
  • Profile picture of Guillaume Bidault
    Role: Post Doctoral
    Affiliation(s): Metabolic Research Laboratories
    Research Summary:
    Department: Institute of Metabolic Science : Research Interests: Obesity is a chronic inflammatory disease characterized by adipose tissue infiltration with macrophages contributing to the metabolic and cardiovascular complications of obesity. M... Read more
  • Profile picture of Clemence Blouet
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    My work focuses on the characterization of brain nutrient-sensing circuits implicated in the regulation of energy homeostasis. This research is done through 3 main axes: 1. the characterization of molecular mechanisms implicated in brain nutrie... Read more
  • Profile picture of Sophie Buller
    Role: PhD Student
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    Department of Clinical Biochemistry, Metabolic Research Laboratories
  • Profile picture of Mark Campbell
    Role: Assistant Staff
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    My research involves the study of the mechanisms that contribute to pathogenesis of obesity and associated metabolic alterations such as insulin resistance. More specifically, my interest lies in the contributing factors that lead to fat deposition o... Read more
  • Profile picture of Stefania Carobbio
    Role: Post Doctoral
    Affiliation(s): Metabolic Research Laboratories
    Research Summary:
    I study allostatic mechanisms taking place in adipose tissue in response to states of obesity and morbid obesity. These states are typically associated with insulin resistance and I aim to understand how these compensatory mechanisms allow the mainte... Read more
  • Profile picture of Anthony Coll
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    My work focuses on the molecular mechanism controlling food intake and energy expenditure. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to combine murine genetics and whole animal ph... Read more
  • Profile picture of Miguel Constância
    Role: Principal Investigator
    Affiliation(s): Metabolic Research LaboratoriesDepartment of Obstetrics and Gynaecology
    Research Summary:
    Epigenetics is an exciting and rapidly moving field that impacts basic biomedical research and clinical medicine. Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNAs provide dynamic, heritable and reversible ways ... Read more
  • Profile picture of Eloise Cross
    Role: Other
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    Department of Clinical Biochemistry, Metabolic Research Laboratories
  • Profile picture of Laura Dearden
    Role: Post Doctoral
    Affiliation(s): Metabolic Research Laboratories
    Research Summary:
    I am investigating how developing in an environment of maternal obesity and gestational diabetes alters development of the hypothalamus in offspring, and how disrupted hypothalamic development underpins the changes in feeding behaviour that ultimatel... Read more
  • Profile picture of Ana Rita Dias
    Role: Assistant Staff
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    Department of Clinical Biochemistry, Metabolic Research Laboratories
  • Profile picture of David Dunger
    Role: Principal Investigator
    Affiliation(s): Department of Paediatrics, Metabolic Research Laboratories
    Research Summary:
    David Dunger is a paediatric clinical scientist with over 30 years experience in three key research areas. 1) Pathogenesis of type 1 diabetes and its complications: In 1986 he initiated the Oxford Regional prospective study of childhood di... Read more
  • Profile picture of Mark Evans
    Role: Principal Investigator
    Affiliation(s): Department of Medicine, Metabolic Research Laboratories
    Research Summary:
    I am interested in (1) how brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism (2) how defences against hypoglycaemia (low blood sugar) may become abnormal in diabetes (3) the short and long term e... Read more
  • Profile picture of I. Sadaf Farooqi
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    The long term goal of our research is to understand the molecular and physiological pathways involved in the regulation of human appetite and body weight. To this end, we use a number of complementary genetic strategies to study over 5,500 patients w... Read more
  • Profile picture of Denise Fernandez-Twinn
    Role: Post Doctoral
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories, MRC Metabolic Diseases Unit
    Research Summary:

    Programmed changes in miRNA expression link early life nutrition to long-term health.  Specifically, my work has shown that miR-483-3p is up-regulated in adipose tissue from low birth-weight adult hu... Read more

  • Profile picture of Fiona Gribble
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    Hormones from the gut are central to the control of appetite and insulin release. Drugs based on the gut hormone glucagon-like peptide-1 (GLP-1) have proved highly successful for treating type 2 diabetes, and also suppress food intake. In collaborati... Read more
  • Profile picture of John Grünberg
    Role: Post Doctoral
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    I am a devoted and focused person who received my bachelor degree and Masters degree from the Institute of Technology at Linköping University. My bachelor degree is in chemical biology and my Master degree is in molecular genetics and physiology. I ... Read more
  • Profile picture of John Grünberg
    Role: Post Doctoral
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories, Wellcome Trust Sanger Institute
    Research Summary:
    I have a bachelor degree in chemical biology from Institute of Technology at Linköping University as well as a Master degree in Molecular Genetics and Physiology. My Master thesis was done at the Department of Cell Biology at Linköping University h... Read more