Member Listing

Name

Anthony Coll

Affiliation

Department of Clinical Biochemistry, Metabolic Research Laboratories

Title

Dr

Role

Principal Investigator

Research Summary

My work focuses on the molecular mechanism controlling food intake and energy expenditure. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to combine murine genetics and whole animal physiological studies to address these issues. I have a longstanding interest in the leptin-melanocortin pathway and in collaboration with colleagues in the IMS (O’Rahilly, Farooqi, Yeo) continue to use murine models to explore the biology behind genomic variants associated with metabolic disorders, identified through large scale human genetic studies.

My research is funded by the MRC.

Expertise

Biochemistry and Molecular Biology, Cell Biology, Endocrinology, Neuroscience

Selected Publications

Tung YC, Yeo GSH, O’Rahilly S, Coll AP. FTO and obesity;changing focus at a complex locus. Cell Metab 2014, in press

Larder R, Lim CT, Coll AP. Genetic aspects of human obesity. Handb Clin Neurol. 2014;124:93-106. PMID: 25248581.

Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann, F, O’Rahilly S, Gribble FM. Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8. PMID: 25028498. PMCID: PMC4121845.

Coll AP, Yeo GS. The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis. Curr Opin Pharmacol. 2013 Dec;13(6):970-6. PMID: 24075719.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O’Rahilly S, Yeo GS. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. PMID: 23359686. PMCID: PMC3574930.

Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, Zhao Q, Caballero OL, Larder R, Coll AP, O’Rahilly S, Brindle KM, Teichmann SA, Tuveson DA, Fearon DT. Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. J Exp Med. 2013 Jun 3;210(6):1137-51. PMID: 23712428. PMCID: PMC3674708.

McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O’Rahilly S, Ashcroft FM, Coll AP, Cox RD.(2013). Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet. 2013 Jan;9(1):e1003166. doi: 10.1371/journal.pgen.1003166. Epub 2013 Jan 3. PMID: 23300482.

Corrander MP, Rimmington D, Challis BG, O’Rahilly S, Coll AP. (2011). Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency. Endocrinology, 152(5):1819-28. PMID: 21363936. PMCID: PMC3137464.

Corrander MP, Coll AP. (2011). Melanocortins and body weight regulation: Glucocorticoids, Agouti-related protein and beyond. Eur J Pharmacol, 660(1):111-8. PMID: 21199644.

Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP. (2011). Where to go with FTO? Trends Endocrinol Metab, 22(2):53-9. PMID: 21131211.

Corander MP, Challis BG, Thompson EL, Jovanovic Z, Loraine Tung YC, Rimmington D, Huhtaniemi IT, Murphy KG, Kemal Topaloglu A, Yeo GS, O’Rahilly S, Dhillo WS, Semple RK, Coll AP. (2010). The effects of neurokinin B upon gonadotrophin release in male rodents. J Neuroendocrinol, 22(3):181-7. PMID: 20041982.

Corander MP, Fenech M, Coll AP. (2009). Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage. Circulation, 120(22):2260-8. PMID: 19948994. PMCID: PMC2880450.

Coll AP, Yeo GS, Farooqi IS, O’Rahilly S. (2008). SnapShot: the hormonal control of food intake. Cell, 135(3):572.e1-2. PMID: 18984167.

Coll AP, Loraine Tung YC. (2009). Pro-opiomelanocortin (POMC)-derived peptides and the regulation of energy homeostasis. Mol Cell Endocrinol, 300(1-2):147-51. PMID: 18840502.

Prieur X, Tung YC, Griffin JL, Farooqi IS, O’Rahilly S, Coll AP. (2008). Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology, 149(11):5432-9. PMID: 18635658. PMCID: PMC2629739.

Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP, Nakagawa Y, Ohzeki T, Seckl JR, Chapman KE. (2008). Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta. Mol Endocrinol, 22(9):2049-60. PMID: 18617597.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O’Rahilly S, Schofield CJ. (2007). The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science, 30;318(5855):1469-72. PMID: 17991826. PMCID: PMC2668859.

Tung YC, Rimmington D, O’Rahilly S, Coll AP. (2007). Pro-opiomelanocortin modulates the thermogenic and physical activity responses to high-fat feeding and markedly influences dietary fat preference. Endocrinology, 148(11):5331-8. PMID: 17717049. PMCID: PMC2204084.

López M, Lage R, Tung YC, Challis BG, Varela L, Virtue S, O’Rahilly S, Vidal-Puig A, Diéguez C, Coll AP. (2007). Orexin expression is regulated by alpha-melanocyte-stimulating hormone. J Neuroendocrinol, 19(9):703-7. PMID: 17680885. PMCID: PMC2637479.

Michailidou Z, Coll AP, Kenyon CJ, Morton NM, O’Rahilly S, Seckl JR, Chapman KE. (2007). Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone. J Endocrinol, 194(1):161-70. PMID: 17592030. PMCID: PMC1994568.

Coll AP, Farooqi IS, O’Rahilly S. The hormonal control of food intake. (2007) Cell, 129(2):251-62. PMID: 17448988. PMCID: PMC2202913.

Hutchinson WL, Coll AP*, Gallimore JR, Tennent GA, Pepys MB. (2007). Is leptin an important physiological regulator of CRP? Nat Medicine, 13(1):17-18 (* joint first author). PMID: 17206123.

Tung YC, Piper SJ, Yeung D, O’Rahilly S, Coll AP. (2006). A comparative study of the central effects of specific POMC-derived melanocortin peptides on food intake and body weight in Pomc null mice. Endocrinology, 147(12):5940-5947. PMID: 16959830. PMCID: PMC2204083.

Coll AP, Challis BG, López M, Piper SJ , Yeo GSH, O’Rahilly S. (2005). Pro-opiomelanocortin deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes, 54(8),2269-76. PMID: 16046291.