Member Listing

Name

Alice Adriaenssens

Affiliation

Department of Clinical Biochemistry, Metabolic Research Laboratories, MRC Metabolic Diseases Unit

Title

Dr

Role

Post Doctoral

Research Summary

I am a research associate working in the Institute of Metabolic Science with Fiona Gribble and Frank Reimann. My work focuses on characterising the central targets of incretin hormones.

Expertise

Biochemistry and Molecular Biology, Cell Biology

Selected Publications

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM.
Diabetologia. 2016 Oct;59(10):2156-65. doi: 10.1007/s00125-016-4033-1. Epub 2016 Jul 7.

A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.
Adriaenssens A, Lam BY, Billing L, Skeffington K, Sewing S, Reimann F, Gribble F.
Endocrinology. 2015 Nov;156(11):3924-36. doi: 10.1210/en.2015-1301. Epub 2015 Aug 4.

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.
Stamenkovic JA, Andersson LE, Adriaenssens AE, Bagge A, Sharoyko VV, Gribble F, Reimann F, Wollheim CB, Mulder H, Spégel P.
Biochem J. 2015 May 15;468(1):49-63. doi: 10.1042/BJ20140697.

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.
Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM.
Nat Commun. 2014 Aug 22;5:4639. doi: 10.1038/ncomms5639.

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.
Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens A, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann F, O’Rahilly S, Gribble FM.
Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8. doi: 10.1073/pnas.1411413111. Epub 2014 Jul 15.

Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model.
Richards P, Parker HE, Adriaenssens AE, Hodgson JM, Cork SC, Trapp S, Gribble FM, Reimann F.
Diabetes. 2014 Apr;63(4):1224-33. doi: 10.2337/db13-1440. Epub 2013 Dec 2.

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.
Parker HE, Adriaenssens A, Rogers G, Richards P, Koepsell H, Reimann F, Gribble FM.
Diabetologia. 2012 Sep;55(9):2445-55. doi: 10.1007/s00125-012-2585-2. Epub 2012 May 26.