Member Listing

Name

John Grünberg

Affiliation

Department of Clinical Biochemistry, Metabolic Research Laboratories

Title

Dr

Role

Post Doctoral

Research Summary

I am a devoted and focused person who received my bachelor degree and Masters degree from the Institute of Technology at Linköping University. My bachelor degree is in chemical biology and my Master degree is in molecular genetics and physiology. I started my PhD-education in the autumn of 2010 at the Lundberg Laboratory for Diabetes Research in the department of Molecular and Clinical Medicine/Diabetes at The Sahlgrenska Academy, Göteborg University. In the spring of 2015 I defended my thesis “WISP2 – A Novel Adipokine Related to Obesity and Insulin Resistance” and continued as a researcher until the end of 2016. In 2017 I started as a Post Doctoral Research Associate working for Professor Antonio Vidal-Puig in the TVPLab at the University of Cambridge.

My research in TVPLab will focus on adipocyte membrane lipid composition and the recently identified gene, the fatty acid desaturase 3, (FADS3). The aim of the project is to understand the mechanisms that enable the adipose to cope with overnutrition induced metabolic stress. These mechanisms are important because they may identify novel strategies to improve adipose tissue function and prevent the adipose tissue dependent complications associated with positive energy balance. Thus, we hypothesize that FADS3, might play an important role mediating adipocyte lipid remodelling. To test this hypothesis we will use a combined in-vivo/in-vitro approach to characterize the effect of ablation of FADS3 on obesity induced metabolic complications.

The focus on qualitative aspects of lipid composition in adipose tissue as a key determinant of the association between obesity with metabolic complications is an original and novel scientific concept with important implications for diagnosis and treatment. This project may provide important insights on the pathogenesis of insulin resistance and its unexplored relationship with the ability of adipose tissue to grow under conditions of positive energy balance.
The identification of both substrates and products of FADS3 action may open new avenues of research focused on nutrition/dietary lipids and health. This information has enormous value and when confirmed will be used to develop diagnostic tools, safe therapeutic drugs and/or nutritional interventions backed up by knowledge based evidence and strong rationale.

Expertise

Biochemistry and Molecular Biology, Cell Biology

Selected Publications

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance
Grünberg J.R., Hoffmann J.M., Hedjazifar S., Nerstedt A., Jenndahl L., Elvin J., Castellot J., Wei L., Movérare Skrtic S., Ohlsson C., Mannerås Holm L., Bäckhed F., Syed I., Bosch F.,
Saghetelian A., Kahn B.B., Hammarstedt A., Smith U. Sci. Rep. 7, 43515; doi: 10.1038/srep43515 (2017).

The Novel Secreted Adipokine WNT1-Inducible-Signaling Pathway Protein2/Wisp2 is a Mesenchymal Cell Activator of Canonical Wnt.
Grünberg J.R., Hammarstedt A., Hedjazifar S. and Smith U.: J Biol Chem 289:6899-6907, 2014

WISP2 regulates preadipocyte commitment and PPARgamma activation by BMP4
Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J.R., Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M, Smith U. Proc Natl Acad Sci U S A. 110 (7), pp. 2563-2568 2013

The Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells
Jonas Ungerbäck, Nils Elander, John Grünberg, Mikael Sigvardsson, Peter Söderkvist
PLoS ONE, 6 (3), art. no. e17957 2011

Manuscripts:
Increasing blood BMP4 levels in mature mice leads to beige/brown adipose tissue and protection from obesity
J.M Hoffmann, J.R Grünberg, I. Elias, F. Bosch, V. Palsdottir, J-O. Jansson, A. Hammarstedt, S. Hedjazifar, U. Smith: Submitted to Cell Metabolism

Conference articles:

Oral presentations
Transplantation of adipose tissue from mice overexpressing WISP2 increases FAHFAs and glucose tolerance in obese mice
J.R. Grünberg, J.M. Hoffmann, S. Hedjazifar, I. Syed, A. Saghatelian, B.B. Kahn,
A. Hammarstedt, U. Smith
Molecular and Clinical Medicine/Diabetes, Medicine, Göteborg, Sweden
52nd EASD Annual Meeting Munich, Germany 12-16 September 2016

Increased brown fat and insulin sensitivity in obese mice overexpressing WISP2 in the adipose tissue
J.R. Grünberg, J.M. Hoffmann, S. Hedjazifar, A. Nerstedt, L. Jenndahl, J. Castellot, L. Wei, S. Movérare Skrtic, F. Bäckhed, I. Syed, A. Saghetelian, B. Kahn, A. Hammarstedt, U. Smith
Molecular and Clinical Medicine/Diabetes, Medicine, Göteborg, Sweden.
Göteborg Early Career Scientist (GECS)2015 Astra Zenica Mölndal, Sweden 11 December 2015

Increased brown fat and insulin sensitivity in obese mice overexpressing WISP2 in the adipose tissue
J.R. Grünberg, J.M. Hoffmann, S. Hedjazifar, A. Nerstedt, L. Jenndahl, J. Castellot, L. Wei, S. Movérare Skrtic, F. Bäckhed, I. Syed, A. Saghetelian, B. Kahn, A. Hammarstedt, U. Smith
Molecular and Clinical Medicine/Diabetes, Medicine, Göteborg, Sweden.
51th EASD Annual Meeting Stockholm, Sweden 14 – 18 September 2015

The novel adipokine WISP2 regulates adipogenesis and is a canonical Wnt ligand
J.R. Grünberg, A. Hammarstedt, S. Hedjazifar, U. Smith
Molecular and Clinical Medicine/Diabetes, Medicine, Göteborg, Sweden.
49th EASD Annual Meeting Barcelona, Spanien 23 – 27 September 2013

The canonical Wnt activator, WISP 2, is upregulated in hypertrophic obesity and prevents stem cell commitment and adipocyte differentiation
J.R. Grünberg, A. Hammarstedt, L. Jenndahl, S. Hedjazifar, U. Smith;
Molecular and Clinical Medicine/Diabetes, Medicine, Göteborg, Sweden.
47th EASD Annual Meeting Lisbon, Portugal 12 – 16 September 2011