• Profile picture of Professor Margaret Ashcroft
    Role: Principal Investigator
    Affiliation(s): Department of Medicine
    Research Summary:
    The main goal of the Ashcroft laboratory is to understand the key cellular mechanisms involved in hypoxia signalling and control of oxygenation. In particular, we have a strong interest in the hypoxia inducible factor (HIF) family of transcription fa... Read more
  • Profile picture of Gemma Brierley
    Role: Post Doctoral
    Affiliation(s): Department of Clinical BiochemistryInstitute of Metabolic Science
    Research Summary:
    Dr Gemma Brierley completed her PhD at the University of Adelaide where she investigated the interplay between the receptors of the IGF system and how they signal outcomes relevant to cancer biology. She was a Postdoctoral Fellow at the Commonwealth ... Read more
  • Profile picture of Kevin Brindle
    Role: Principal Investigator
    Affiliation(s): CRUK Cambridge Institute, Department of Biochemistry
    Research Summary:
    The primary aim of my laboratory is to develop clinically applicable imaging methods that can be used to detect early tumour responses to treatment. These could be used in early stage clinical trials of new drugs to get an indication of efficacy and... Read more
  • Profile picture of Matthew Collins
    Role: Principal Investigator
    Affiliation(s): Department of Archaeology
    Research Summary:
  • Profile picture of Timothy M Cox
    Role: Principal Investigator
    Affiliation(s): Department of Medicine
    Research Summary:
    We seek to understand the molecular causation of inborn errors of metabolism and to improve their outcome – conducting therapeutic research principally in the field of lysosomal disorders – with special reference to those which affect the brain. ... Read more
  • Profile picture of David Dunger
    Role: Principal Investigator
    Affiliation(s): Department of Paediatrics, Metabolic Research Laboratories
    Research Summary:
    Research Interests

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  • Profile picture of I. Sadaf Farooqi
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry
    Research Summary:
    The long term goal of our research is to understand the molecular and physiological pathways involved in the regulation of human appetite and body weight. To this end, we use a number of complementary genetic strategies to study over 5,500 patients w... Read more
  • Profile picture of Anne Ferguson-Smith
    Role: Principal Investigator
    Affiliation(s): Department of Genetics
    Research Summary:
    Our lab focuses on the molecular events governing pre- and post-natal mammalian development. Our research is directed towards investigating the developmental role of imprinted genes and the epigenetic mechanism(s) controlling their parental-origin sp... Read more
  • Profile picture of Paul Fletcher
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Neurosciences
    Research Summary:
    My work focuses on questions related to the brain’s reward systems and to how characterisation of these systems, and the complex behaviours that they support, may form a key part of understanding the growing population-wide vulnerability to health-... Read more
  • Profile picture of Abigail Fowden
    Role: Principal Investigator
    Affiliation(s): Department of Physiology, Development and Neuroscience
    Research Summary:
    My research interests are in developmental physiology with particular emphasis on the metabolic and endocrine mechanisms controlling intrauterine development and its long term postnatal consequences. The research takes an integrated approach from the... Read more
  • Profile picture of Fiona Gribble
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    Hormones from the gut are central to the control of appetite and insulin release. Drugs based on the gut hormone glucagon-like peptide-1 (GLP-1) have proved highly successful for treating type 2 diabetes, and also suppress food intake. In collaborati... Read more
  • Profile picture of Christoph Hess
    Role: Principal Investigator
    Affiliation(s): Department of Medicine
    Research Summary:
    The metabolic repertoire of immune cells – which encompasses metabolic enzymes/pathways, the available nutrient sensors and metabolic checkpoint kinases, and the epigenetic programming of metabolic genes – enables and modulates specific immune fu... Read more
  • Profile picture of Rita Horvath
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Neurosciences
    Research Summary:
    Rita Horvath is a clinical academic who was trained as a neurologist in Budapest, Hungary and completed her PhD on mitochondrial disease. She started laboratory research in Eric Shoubridge`s laboratory at the Montreal Neurological Institute as a visi... Read more
  • Profile picture of Roman Hovorka
    Role: Principal Investigator
    Affiliation(s): Department of Paediatrics, Metabolic Research Laboratories
    Research Summary:
    Mathematical modeling to support diagnosis and treatment of metabolic diseases Our aim is to support the diagnosis and treatment of metabolic diseases using mathematical modeling techniques with particular focus on diabetes. We use existing and de... Read more
  • Profile picture of Laura Itzhako
    Role: Principal Investigator
    Affiliation(s): Department of Pharmacology
    Research Summary:
    Department of Pharmacology
  • Profile picture of Jørgen Jensen
    Role: Principal Investigator
    Affiliation(s): Institute of Metabolic Science and Norwegian School of Sport Sciences
    Research Summary:
    My research interests are: 1) the mechanisms by which muscle contraction stimulates glucose uptake and improves insulin action, and 2) the mechanisms by which exercise training improves whole body glucose homeostasis in humans. The human studies incl... Read more
  • Profile picture of Jacek Mokrosinski
    Role: Post Doctoral
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    My main research interests and speciality lie in the field of molecular in vitro pharmacology of 7-transmembrane G-protein coupled receptors (GPCR). I am studying structural and functional properties of rhodopsin-like (class A) GPCRs. I am a postdoct... Read more
  • Profile picture of Stephen O'Rahilly
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    I have a long-standing interest in the aetiology and pathophysiology of human metabolic and endocrine disease and how such information might be used to improve diagnosis, prognostication, therapy and prevention. I have a long-standing, close, collabo... Read more
  • Profile picture of Ommar Omarjee
    Role: Post Doctoral
    Affiliation(s): Department of Medicine
    Research Summary:
    I am currently a research associate in Professor Christoph Hess's group at CITIID on the Cambridge Biomedical Campus. My reaseach interest lies in understand the underpinnings of immunotebolism in the human immune system in both physiological and pat... Read more
  • Profile picture of Ken Ong
    Role: Principal Investigator
    Affiliation(s): Department of Medicine, Department of Paediatrics, MRC Epidemiology Unit
    Research Summary:
    Ken Ong leads the Unit’s Growth and Development programme. His research identified rapid postnatal growth, weight gain and reproductive timing as determinants of, and also potential targets for the prevention of, childhood obesity, type 2 diabetes ... Read more