• Profile picture of Mark Evans
    Role: Principal Investigator
    Affiliation(s): Department of Medicine, Metabolic Research Laboratories
    Research Summary:
    I am interested in (1) how brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism (2) how defences against hypoglycaemia (low blood sugar) may become abnormal in diabetes (3) the short and long term e... Read more
  • Profile picture of I. Sadaf Farooqi
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry
    Research Summary:
    The long term goal of our research is to understand the molecular and physiological pathways involved in the regulation of human appetite and body weight. To this end, we use a number of complementary genetic strategies to study over 5,500 patients w... Read more
  • Profile picture of Daniel Fazakerley
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Institute of Metabolic Science -Metabolic Research Laboratories
    Research Summary:
    The Fazakerley group is interested in understanding the molecular details of insulin-stimulated glucose transport, and how this process breaks down in disease. One of the ways in which insulin lowers blood glucose is through stimulating gluco... Read more
  • Profile picture of Anne Ferguson-Smith
    Role: Principal Investigator
    Affiliation(s): Department of Genetics
    Research Summary:
    Our lab focuses on the molecular events governing pre- and post-natal mammalian development. Our research is directed towards investigating the developmental role of imprinted genes and the epigenetic mechanism(s) controlling their parental-origin sp... Read more
  • Profile picture of Paul Fletcher
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Neurosciences
    Research Summary:
    My work focuses on questions related to the brain’s reward systems and to how characterisation of these systems, and the complex behaviours that they support, may form a key part of understanding the growing population-wide vulnerability to health-... Read more
  • Profile picture of Abigail Fowden
    Role: Principal Investigator
    Affiliation(s): Department of Physiology, Development and Neuroscience
    Research Summary:
    My research interests are in developmental physiology with particular emphasis on the metabolic and endocrine mechanisms controlling intrauterine development and its long term postnatal consequences. The research takes an integrated approach from the... Read more
  • Profile picture of Gwen Le Gall
    Role: Principal Investigator
    Affiliation(s): UEA
    Research Summary:
    My focus is to use metabolomics and lipidomics to study human metabolism and contribute to research in human nutrition and disease prevention. I believe that establishing links between fluid/tissue metabolites and disease is one of the first steps... Read more
  • Profile picture of Fiona Gribble
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories
    Research Summary:
    Hormones from the gut are central to the control of appetite and insulin release. Drugs based on the gut hormone glucagon-like peptide-1 (GLP-1) have proved highly successful for treating type 2 diabetes, and also suppress food intake. In collaborati... Read more
  • Profile picture of Phill Hawkins
    Role: Principal Investigator
    Affiliation(s): The Babraham Institute
    Research Summary:
    The programmes of work in the laboratory are currently aimed at understanding the molecular mechanisms and physiological significance of intracellular signalling networks which involve a family of enzymes called phosphoinositide 3OH-kinases (PI3Ks). ... Read more
  • Profile picture of Christoph Hess
    Role: Principal Investigator
    Affiliation(s): Department of Medicine
    Research Summary:
    The metabolic repertoire of immune cells – which encompasses metabolic enzymes/pathways, the available nutrient sensors and metabolic checkpoint kinases, and the epigenetic programming of metabolic genes – enables and modulates specific immune fu... Read more
  • Profile picture of Rita Horvath
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Neurosciences
    Research Summary:
    Rita Horvath is a clinical academic who was trained as a neurologist in Budapest, Hungary and completed her PhD on mitochondrial disease. She started laboratory research in Eric Shoubridge`s laboratory at the Montreal Neurological Institute as a visi... Read more
  • Profile picture of Jon Houseley
    Role: Principal Investigator
    Affiliation(s): The Babraham Institute
    Research Summary:
    We tend to think of each gene occurring once in the human genome sequence, but this is not exactly true as a large proportion of the human genome is composed of repeated sequences. Genes within repeated regions will occur more than once in the genome... Read more
  • Profile picture of Roman Hovorka
    Role: Principal Investigator
    Affiliation(s): Department of Paediatrics, Metabolic Research Laboratories
    Research Summary:
    Mathematical modeling to support diagnosis and treatment of metabolic diseases Our aim is to support the diagnosis and treatment of metabolic diseases using mathematical modeling techniques with particular focus on diabetes. We use existing and de... Read more
  • Profile picture of Laura Itzhako
    Role: Principal Investigator
    Affiliation(s): Department of Pharmacology
    Research Summary:
    Department of Pharmacology
  • Profile picture of Jørgen Jensen
    Role: Principal Investigator
    Affiliation(s): Institute of Metabolic Science and Norwegian School of Sport Sciences
    Research Summary:
    My research interests are: 1) the mechanisms by which muscle contraction stimulates glucose uptake and improves insulin action, and 2) the mechanisms by which exercise training improves whole body glucose homeostasis in humans. The human studies incl... Read more
  • Profile picture of Tomasz Kostrzewski
    Role: Principal Investigator
    Affiliation(s): CN Bio Innovations
    Research Summary:
  • Profile picture of Albert Koulman
    Role: Principal Investigator
    Affiliation(s): Department of Clinical Biochemistry, Metabolic Research Laboratories, MRC Epidemiology Unit, MRC Human Nutrition Research
    Research Summary:
    My main research focus involves developing cutting-edge analytical methods to measure specific metabolites and nutrients, and using these methods to facilitate the further understanding of our metabolism and of the role of metabolism in disease. The ... Read more
  • Profile picture of Nicholas Ktistakis
    Role: Principal Investigator
    Affiliation(s): The Babraham Institute
    Research Summary:
    AUTOPHAGY: mechanism and regulators Autophagy (from the Greek self-eating) is a cellular mechanism which generates nutrients for the cell, primarily during times of starvation. Autophagy is also used to eliminate cell material that becomes damaged... Read more
  • Profile picture of Graham Ladds
    Role: Principal Investigator
    Affiliation(s): Department of Pharmacology
    Research Summary:
    Our research is to investigate the molecular basis of signalling bias at family B G protein-coupled receptors (GPCRs). Our interests include the receptors for GLP-1, glucagon, GIP and GLP-2. We are also actively investigating how molecular chaperone ... Read more
  • Profile picture of Claudia Langenberg
    Role: Principal Investigator
    Affiliation(s): MRC Epidemiology Unit
    Research Summary:
    I am a program Leader at the MRC Epidemiology Unit at the University of Cambridge focusing on molecular epidemiology. Our work integrates large-scale genomic and metabolomic data to discover, prioritise and characterize metabolic pathways and test t... Read more