The Rayne Institute, BHF Centre of Research Excellence, Kings College London
I am an associate lecturer in Cardiovascular Division at King’s BHF Centre of Research Excellence with 8 years of cardiac metabolism scientific research experience (at the University of Oxford BHF Centre of Research Excellence, Prof Stefan Neubauer’s group and Prof Michael Shattock’s research group at the Rayne Institute, King’s College London) with the expertise in cellular biochemistry (cardiovascular metabolism, physiology, insulin resistance, chronic renal failure, NMR spectroscopy, metabolomics, mitochondrial biology).I am currently endeavouring to combine my interdisciplinary skills in cardiac physiology, metabolism and NMR to establish my own research niche to investigate the metabolic drivers and consequences of hypoxic fetal programming, role of Nai in diabetic cardiomyopathy and developing NMR techniques to non-invasively, in real time measure free radical production and oxidant stress. I am also an academic tutor (University of Oxford and King’s College London), lecturer, admissions tutor and graduate student supervisor. Furthermore I am actively involved in science outreach projects as a volunteer expert mentor in iSerbia scientific knowledge transfer programme as well as for British Heart Foundation campaigns.
EXPERIMENTAL COMPETENCE & SKILLS
1) Aksentijević, D. Lewis, H. Shattock, MJ. (2016) Assessing cardiac ‘effort’ and oxygen consumption in the Langendorff-perfused heart. Is rate-pressure product of any use? Experimental Physiology
2) Cole, MA*. Abd Jamil*, AH. Heather, LC. Murray,AJ. Sutton,ER. Slingo,M. Sebag-Montefiore, L. Tan, SC. Aksentijević,D et al. (2016) “On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury” FASEB Journal, in press
3) Mansor, LS. Keshavi, M. Aksentijević, D. et al. (2016) Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation, Journal of Physiology 594(2):307-20
4) Eykyn, TR.* Aksentijević, D.* et al. (2015) Multiple quantum filtered 23Na NMR revisited: Ratio of Triple/ Double quantum filtered signals correlate with Nai in the Langendorff perfused mouse heart *authors contributed equally Journal of Molecular and Cellular Cardiology 86:95-101
5) Robb, EL. Gawel, JM. Aksentijević et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine 8;89:883-894
6) Aksentijević, D. et al. (2014) Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity. Journal of Molecular and Cellular Cardiology 75:76-87
7) Chouchani E.* Pell V.* Gaude E. Aksentijević, D. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527):431-5,
8) Aksentijević, D. et al. (2014) Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart. PLOS One, 1;9(10):e109021
10) Ashrafian, H. Czibik, G*,Bellahcene, M* Aksentijević, D. et al. (2012) Fumarate exerts cardioprotective effects via activation of the Nrf2 antioxidant pathway Cell Metabolism 15 (3): 361-371
11) Aksentijević D. et al. (2010) High energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes European Journal of Heart Failure 12:1282-1289.
12) Aksentijević, D. Bhandari, S. Seymour, A. M. (2009) Insulin resistance and altered glucose transporter 4 expression in experimental uremia Kidney International 75: 711-8