Member Listing


David Bedford



Other Affiliation




Research Summary

Interested in identifying ways to accelerate the repurposing of drugs for rare diseases.


Biochemistry and Molecular Biology, Cell Biology, Other

Selected Publications

Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.
Sci Reports 2018 Mar 2; 8(1)
Garner KL, Betin VMS, Pinto V, Graham M, Abgueguen E, Barnes M, Bedford DC, McArdle CA, Coward RJM.

Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviours in Mice.
PLoS One 2016 Jan 5; 11(1).
Zheng F, Kasper LH, Bedford DC, Lerach S, Teubner BJ, Brindle PK.

Prox1 determines hepatocyte verus cholangiocyte fate choices in hepatoblasts.
Development 2014 Feb; 141(3):538-47.
Seth A, Bedford DC, Guez F, Kaestner K, Brindle PK, Sosa-Pineda B.

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.
Cell Metabolism 2011 Aug 3;14(2):219-230.
Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, Brindle PK.

S6K1: Reducing the RiSKs of aging.
Dis Model Mech. 2010 Mar-Apr;3(3-4):123-4.
Bedford DC.

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.
Epigenetics. 2010 Jan;5(1):9-15.
Bedford DC, Kasper LH, Fukuyama T, Brindle PK.

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.
Diabetologia. 2006 Mar; 49(3): 552-61.
Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ.

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.
J Clin Invest. 2005 Apr; 115(4): 940-50.
Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ.

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Anal Biochem. 2003 Sep 1; 320(1): 66-74.
Elaine Barrie S, Eno-Amooquaye E, Hardcastle A, Platt G, Richards J, Bedford D, Workman P, Aherne W, Mittnacht S, Garrett MD.

Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6.
J Biol Chem. 2001 May 18; 276(20): 16617-23. Epub 2001 Feb 06.
Fry DW, Bedford DC, Harvey PH, Fritsch A, Keller PR, Wu Z, Dobrusin E, Leopold WR, Fattaey A, Garrett MD.

Other field of expertise

Drug Discovery