Interested in identifying ways to accelerate the repurposing of drugs for rare diseases.
Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.
Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviours in Mice.
Prox1 determines hepatocyte verus cholangiocyte fate choices in hepatoblasts.
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.
S6K1: Reducing the RiSKs of aging.
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.
Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.
The role of insulin receptor substrate 2 in hypothalamic and beta cell function.
High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6.
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