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Eunus S. Ali



Other Affiliation

Feinberg School of Medicine, Northwestern University


Post Doctoral

Research Summary

Improving obesity- and cancer-related metabolic dysfunctions by investigating and controlling body’s’ signaling pathways and metabolism has been the focus of Eunus S. Ali’s research. Using biochemistry and cell biology, he works at the molecular level to identify how to efficiently restore aberrant cellular signaling dynamics in cancer, diabetes, aging and neurological diseases. He has published some significant works in this area in several well-ranked journals including Molecular Cell, Semin Cancer Biol, Trends Endocrinol and Metab as first author. Prior to Postdoc with Dr. Issam Ben-Sahra at Northwestern University, his PhD was completed under the supervision of Dr. Greg Barritt at Flinders University, and MS at Stockholm University Arrhenius Laboratory with Dr. Göran Widmalm.


Biochemistry and Molecular Biology, Bioinformatics, Cancer, Cell Biology, Developmental Biology, Epigenetics, Endocrinology, Genetics, Immunology, Neuroscience, Protein Chemistry

Selected Publications

Ali ES, Sahu U, Villa E, O’Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Mol Cell. 2020 Jun 18;78(6):1178-1191.e6. doi: 10.1016/j.molcel.2020.05.001. Epub 2020 Jun 1. PubMed PMID: 32485148; PubMed Central PMCID: PMC7306006.

Ali ES, Rychkov GY, Barritt GJ. TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species. Antioxidants (Basel). 2021 Aug 3;10(8). doi: 10.3390/antiox10081243. Review. PubMed PMID: 34439491; PubMed Central PMCID: PMC8389341.

Islam MT, Quispe C, Islam MA, Ali ES, Saha S, Asha UH, Mondal M, Razis AFA, Sunusi U, Kamal RM, Kumar M, Sharifi-Rad J. Effects of nerol on paracetamol-induced liver damage in Wistar albino rats. Biomed Pharmacother. 2021 Aug;140:111732. doi: 10.1016/j.biopha.2021.111732. Epub 2021 Jun 12. PubMed PMID: 34130201.

Ali ES, Girard D, Petrovsky N. Impaired Ca2+ signaling due to hepatic steatosis mediates hepatic insulin resistance in Alström syndrome mice that is reversed by GLP-1 analog treatment. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C187-C198. doi: 10.1152/ajpcell.00020.2021. Epub 2021 Jun 9. PubMed PMID: 34106786.

Villa E, Sahu U, O’Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Mol Cell. 2021 May 20;81(10):2076-2093.e9. doi: 10.1016/j.molcel.2021.03.009. Epub 2021 Mar 22. PubMed PMID: 33756106; PubMed Central PMCID: PMC8141029.

Shireman JM, Atashi F, Lee G, Ali ES, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS, James CD, Stupp R, Kumthekar P, Horbinski CM, Ben-Sahra I, Ahmed AU. De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma. Brain. 2021 May 7;144(4):1230-1246. doi: 10.1093/brain/awab020. PubMed PMID: 33855339; PubMed Central PMCID: PMC8105035.

Ali ES, Rychkov GY, Barritt GJ. Targeting Ca2+ Signaling in the Initiation, Promotion and Progression of Hepatocellular Carcinoma. Cancers (Basel). 2020 Sep 24;12(10). doi: 10.3390/cancers12102755. Review. PubMed PMID: 32987945; PubMed Central PMCID: PMC7600741.

Ali ES, Rychkov GY, Barritt GJ. Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma. Cell Calcium. 2019 Sep;82:102057. doi: 10.1016/j.ceca.2019.102057. Epub 2019 Jul 26. Review. PubMed PMID: 31401389.

Villa E, Ali ES, Sahu U, Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers (Basel). 2019 May 17;11(5). doi: 10.3390/cancers11050688. Review. PubMed PMID: 31108873; PubMed Central PMCID: PMC6562601.

Ali ES, Petrovsky N. Calcium Signaling As a Therapeutic Target for Liver Steatosis. Trends Endocrinol Metab. 2019 Apr;30(4):270-281. doi: 10.1016/j.tem.2019.02.005. Epub 2019 Mar 5. Review. PubMed PMID: 30850262.

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