Research Associate in Computational Genomics in Prof Sadaf Farooqi’s GOOS team on genomics of obesity/thinness and rare diseases. A particular focus is the role of genomic variants in hypothalamic dysfunction. We perform computational analysis of whole-exome sequencing, RNA-seq and metabolomics together with ‘omics of hypothalamic function derived from model systems.
Joined the GOOS team with several years’ post-doctoral experience in cancer genomics (King’s College London) and a background in Mathematics (MA/Part III/MMath, Cambridge) and Computational Biology/Bioinformatics (PhD, Functional Genomics group at EMBL-EBI).
Full publication list at Google Scholar.
Bochukova EG, Lawler K, Croizier S, Keogh JM, Patel N, Strohbehn G, Lo KK, Humphrey J, Hokken-Koelega A, Damen L, Donze S, Bouret SG, Plagnol V, Farooqi IS. A transcriptomic signature of the hypothalamic response to fasting and BDNF deficiency in Prader-Willi syndrome. Cell Reports 22(13):3401–3408 (2018) [DOI]
Lawler K, Papouli E, Naceur-Lombardelli C, Mera A, Ougham K, Tutt A, Kimbung S, Hedenfalk I, Zhan J, Zhang H, Buus R, Dowsett M, Ng T, Pinder SE, Parker P, Holmberg L, Gillett C, Grigoriadis A, Purushotham A. Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study. Breast Cancer Res 19:113 (2017) [DOI][PMID:29029636]
*Suh Y/*Lawler K, Henley-Smith R, Pike L, Leek R, Barrington S, Odell EW, Ng T, Pezzella F, Guerrero-Urbano T, Tavassoli M. Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma. Br J Cancer 116:8, 1057-1064 (2017) [DOI][PMID:28324887]
Irshad S, Flores-Borja F, Lawler K, Monypenny J, Evans R, Male V, et al. RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers. Cancer Res 77:5, 1083-1096 (2017) [DOI][PMID:28082403]
*Marguerat S/*Lawler K, Brazma A, Bähler J. Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress. RNA Biol 11:6, 702-714 (2014) [DOI][PMID:25007214]
Lawler K, Hammond-Kosack K, Brazma A, Coulson RMR. Genomic clustering and co-regulation of transcriptional networks in the pathogenic fungus Fusarium graminearum. BMC Syst Biol 7:1, 52 (2013) [DOI][PMID:23805903]