I am a postdoctoral research associate in the laboratory of Professor Sadaf Farooqi. I am studying the roles that novel mutations have on individuals with early onset obesity. I use molecular, biochemical and microscopy techniques to functionally characterise the effects these mutations have on protein function in an attempt to explain how they might contribute to obesity in the mutation carriers.
Banton, M. C., Inder, K. L., Valk, E, Rudd, C. E. and Schneider H. (2014) Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression. Mol. Cell. Biol. 34: 1486-1499.
Pearce, L. R., Atanassova, N., Banton, M. C., Bottomley B., van der Klaauw, A. A., Revelli, J. P., Hendricks, A., Keogh, J. M., Henning, E., Doree, D., Jeter-Jones, S., Garg, S., Bochukova, E. G., Bounds, R., Ashford, S., Gayton, E., Hindmarsh, P. C., Shield, J. P., Crowne, E., Barford, D., Wareham, N. J., UK10K consortium, O’Rahilly, S., Murphy, M. P., Powell, D. R., Barroso, I. and Farooqi, I., S. (2013) KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell. 155: 765-777