Member Listing


Madhu Basetti


CRUK Cambridge Institute





Research Summary

My major research interests are in developing in vivo and ex vivo MR methods (using MRI and MRS) for early diagnosis of cancer and prognosis of therapy. Other interests include NMR based metabolomics to understand cancer biology.


Biochemistry and Molecular Biology, Bioinformatics, Cancer, Systems Biology

Selected Publications

1. ApcMin/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon.
Madhu B, Uribe-Lewis S, Bachman M, Murrell A, Griffiths JR.
Sci Rep. 2020 Aug 12;10(1):13616. doi: 10.1038/s41598-020-70579-w. PMID: 32788746.

2. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.
Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson RS.
Cell Metab. 2018 Apr 3;27(4):898-913.e7. doi: 10.1016/j.cmet.2018.02.020. PMID: 29617647

3. Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Casey RT, McLean MA, Madhu B, Challis BG, Ten Hoopen R, Roberts T, Clark GR, Pittfield D, Simpson HL, Bulusu VR, Allinson K, Happerfield L, Park SM, Marker A, Giger O, Maher ER, Gallagher FA.
JCO Precis Oncol. 2018 Mar 29;2:1-12. doi: 10.1200/PO.17.00191. PMID: 30949620 Free PMC article.

4. Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.
Madhu B, Jauhiainen A, McGuire S, Griffiths JR.
PLoS One. 2017 Oct 25;12(10):e0185980. doi: 10.1371/journal.pone.0185980. eCollection 2017. PMID: 29069098 Free PMC article.

5. Special Issue: Cancer Metabolism.
Basetti M.
Metabolites. 2017 Aug 9;7(3):41. doi: 10.3390/metabo7030041. PMID: 28792436 Free PMC article.

6. Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy.
Madhu B, Shaw GL, Warren AY, Neal DE, Griffiths JR.
Metabolomics. 2016;12:120. doi: 10.1007/s11306-016-1055-0. Epub 2016 Jun 30. PMID: 27429605 Free PMC article.