I am interested in (1) how brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism (2) how defences against hypoglycaemia (low blood sugar) may become abnormal in diabetes (3) the short and long term effects of episodes of hypoglycaemia on brain (4) new and innovative technology for monitoring and managing diabetes, including the development of closed loop insulin pump systems (the “artificial pancreas”).
My research is currently or has recently been supported by the Juvenile Diabetes Research Foundation (JDRF), Diabetes UK, Diabetes Research Wellness Foundation (DRWF), Evelyn Trust, MRC, Wellcome Trust , National Institute for Health Research (NIHR), Sir Jules Thorn Trust and Yousef Jameel Scholarship.
Leelarathna L, Dellweg S, Mader JK, Barnard K, Benesch C, Ellmerer M, Heinemann L, Kojzar H, Thabit H, Wilinska ME, Wysocki T, Pieber TR, Arnolds S, Evans ML, Hovorka R; AP@home consortium. Assessing the effectiveness of 3 months day and night home closed-loop insulin delivery in adults with suboptimally controlled type 1 diabetes: a randomised crossover study protocol. BMJ Open. 2014 Sep 3;4(9):e006075. PMID: 25186158. PMCID: PMC4158197.
Burke LK, Doslikova B, D’Agostino G, Garfield AG, Farooq G, Burdakov D, Low M, Evans ML, Billups B, Heisler LK. 5-HT obesity medication efficacy via POMC activation is maintained during aging. Accepted Endocrinology June 2014. PMID: 25051442.
Thabit H, Lubina-Solomon A, Stadler M, Leelarathna L, Walkinshaw E, Pernet A, Allen JM, Iqbal A, Choudhary P, Kumareswaran K, Nodale M, Nisbett C, Wilinska ME, Dunger DB, Heller SR, Amiel SA, Evans ML, Hovorka R. Home use of closed loop insulin delivery improves overnight glucose control in adults with type 1 diabetes: A four-week multicentre randomised crossover study. Accepted Lancet Diabetes and Endo May 2014. PMID: 24943065. PMCID: PMC4165604.
Yetisen A, Montelongo Y, Vasconcellos F, Neupane S, Butt H, Qasim M, Blyth J, Burling K, Carmody J, Evans M, Wilkinson T, Kubota L, Monteiro M, Lowe, C. Reusable, Robust and Accurate Laser-Generated Photonic Nanosensor. Accepted Nanoletters May 2014. PMID: 24844116.
Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Recovery of hypoglycemia awareness in long-standing type 1 diabetes: a multicenter 2×2 factorial RCT comparing insulin pump with multiple daily injections, and continuous with conventional glucose self-monitoring (HypoCOMPaSS). Diabetes Care May 2014 22. pii: DC_140030. PMID: 24854041.
Walton C, Patel M, Pitts D, Knight P, Hoashi S, Evans ML, Turner C, The use of a portable breath analysis device in monitoring type 1 diabetes patients in a hypoglycaemic clamp: Validation with SIFT-MS data.. Accepted Journal of Breath Research March 2014 JBR-100048.R2. PMID: 25190582.
Lalantha Leelarathna, Sibylle Dellweg, Julia K Mader, Janet M. Allen, Carsten Benesch, Werner Doll, Martin Ellmerer, Sara Hartnell, Lutz Heinemann, Harald Kojzar, Lucy Michalewski, Marianna Nodale, Hood Thabit, Malgorzata E. Wilinska, Thomas R Pieber, Sabine Arnolds, Mark L Evans, and Roman Hovorka. Day and night home closed-loop insulin delivery in adults with type 1 diabetes: three-center randomized crossover study. Diabetes Care 2014 Jul;37(7):1931-7. PMID: 24963110.
Garfield AS, Burke LK, Shaw J, Evans ML, Heisler LK. Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia. Accepted Feb 2014 Behav Brain Res. PMID: 24566060. PMCID: PMC4003350.
Thabit H, Kumareswaran K, Haidar A, Leelarathna L, Caldwell K, Elleri D, Allen J, Nodale M, Wilinska ME, Jackson NC, Umpleby AM, Evans ML, Hovorka R. Acute withdrawal of usual anti-hyperglycaemic therapy and replacement with insulin in insulin-naive type 2 diabetes alters glucose turnover. Accepted J Clin Endocrinol Metab Feb 2014. PMID: 24606105.
Leelarathna L, Thabit H, Allen JM, Nodale M, Wilinska ME, Powell K, Lane S, Evans ML, Hovorka R on behalf of the AP@home consortium. Evaluating the Performance of a Novel Embedded Closed-loop System. Accepted J Diab Sci Technol Dec 2013. PMID: 24876577.