Member Listing

Name

Mark Campbell

Affiliation

Department of Clinical Biochemistry, Metabolic Research Laboratories

Title

Mr

Role

Other

Research Summary

Scientific and Operational Excellence Manager
My primary focus is on the scientific and operational management of our murine metabolic and/or cardio metabolic phenotyping programmes. This involves the ongoing assessment and optimisation of the teams’ resources (financial and human), required to carry out our research according to appropriate timelines and defined budgetary targets.
Through the use and dissemination of scientific evidence, appropriate metrics, key performance indicators, knowledge, and experience, my role is involved in the identification and mitigation of process failures in order to improve workflow and productivity, ensure incorporation of best practices, maximize research quality, and ultimately increase the capabilities for the scientific output of the team.

Expertise

Biochemistry and Molecular Biology

Selected Publications

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue
Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018.

P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.
Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018.

Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.
Tsuchiya Y, Peak-Chew SY, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Bakovic J, Malanchuk O, Pereira GC, Kotiadis V, Szabadkai G, Duchen MR, Campbell M, Cuenca SR, Vidal-Puig A, James AM, Murphy MP, Filonenko V, Skehel M, Gout I.
Biochem J. 2017.

Sphingolipids and glycerophospholipids – The “ying and yang” of lipotoxicity in metabolic diseases.
Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Prog Lipid Res. 2017.

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.
Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015.

Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome.
Sanghez V, Razzoli M, Carobbio S, Campbell M, McCallum J, Cero C, Ceresini G, Cabassi A, Govoni P, Franceschini P, de Santis V, Gurney A, Ninkovic I, Parmigiani S, Palanza P, Vidal-Puig A, Bartolomucci A. Psychoneuroendocrinology. 2013.

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction.
Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal Puig A, Fernández-Real JM. Diabetologia. 2013

New Role for Lipocalin Prostaglandin D Synthase in the Regulation of Brown Adipose Tissue Substrate Utilization.
Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. Diabetes. August 2012

Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.
Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A. PLoS One. July 2012

Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model.
Martínez-García C, Izquierdo A, Velagapudi V, Vivas Y, Velasco I, Campbell M, Burling K, Cava F, Ros M, Oresic M, Vidal-Puig A, Medina-Gomez G. Dis Model Mech. September 2012

Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass.
Vivas Y, Martínez-García C, Izquierdo A, Garcia-Garcia F, Callejas S, Velasco I, Campbell M, Ros M, Dopazo A, Dopazo J, Vidal-Puig A, Medina-Gomez G. BMC Med Genomics. December 2011

Genome-Wide Profiling of MicroRNAs in Adipose Mesenchymal Stem Cell Differentiation and Mouse Models of Obesity.
Bengestrate L, Virtue S, Campbell M, Vidal-Puig A, Hadaschik D, et al. PLoS ONE June 2011

Deletion of the metabolic transcriptional coactivator PGC1{beta} induces cardiac arrhythmia.
Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A, Huang CL Cardiovasc Res. June 2011

Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.
Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešič M, Sethi JK, Vidal-Puig A. Int J Obes (Lond). December 2010

Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig Dis Model Mech November 2009

Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.
Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK. Diabetes. 2009

PPARg2 prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism.
Medina-Gomez G, Gray S, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis K, Jimenez-Linan M, Blount M, Yeo GSH, Lopez M, Seppanen-Laakso T, Ashcroft FM, Oresic M and Vidal-Puig AJ. PLos Gen. April 2007