Member Listing

Name

Olivia Casanueva

Affiliation

The Babraham Institute

Title

Dr

Role

Principal Investigator

Research Summary

Aging can be described as the steady decline in overall function, and increase in incidence of age-related diseases, over an organism’s lifetime. Remarkably, this process can be radically delayed through the reduction of dietary intake without malnutrition, termed Dietary Restriction (DR). In C. elegans, a number of different DR regimens have been developed that affect the aging process to varying degrees and appear to operate via independent and overlapping genetic pathways. The most efficacious DR regimen in worms utilises an axenic (no other species present), nutrient rich media, achieving lifespan extension of up to 150%. This effect is dependent on the absence of as-yet undefined signals from live, metabolically active E. coli, the worm’s food source. In addition, transient DR of otherwise fully fed worms results in stable, long-term changes in gene expression, particularly of genes associated with lipid metabolism, with consequences for longevity, implying a permanent change in the epigenome. We are interested in using metabolomics, epigenomics and modelling to understand how DR can lead to lifespan extension.

Expertise

Genetics, Systems Biology

Selected Publications

Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells.
Lu W, Casanueva MO, Mahowald AP, Kato M, Lauterbach D, Ferguson EL.
PLoS Biol. 2012;10(7):e1001357. doi: 10.1371/journal.pbio.1001357. Epub 2012 Jul 3.

Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans.
Casanueva MO, Burga A, Lehner B.
Science. 2012 Jan 6;335(6064):82-5. doi: 10.1126/science.1213491. Epub 2011 Dec 15.

Predicting mutation outcome from early stochastic variation in genetic interaction partners.
Burga A, Casanueva MO, Lehner B.
Nature. 2011 Dec 7;480(7376):250-3. doi: 10.1038/nature10665.

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.
Garcia SM, Casanueva MO, Silva MC, Amaral MD, Morimoto RI.
Genes Dev. 2007 Nov 15;21(22):3006-16.