I am interested in understanding the role of nutrition metabolism and mitochondrial function in developmental plasticity and the predisposition to metabolic syndrome in adulthood. I am also interested in the coordination between metabolism and cell signalling in malignant transformations. My current work focuses the role of PTEN/SOCS3 signalling and macrophage polarisation in neuronal plasticity.
Day PE, Cleal JK, Field EM, Hanson MA and Lewis RM. Does the basal membrane determine placental glucose transfer kinetics? Placenta 2013, S0143-4004( 13)00588-2
Day PE, Cleal JK, Jackson JJ, Jackson AA, Hanson MA and Lewis RM. Partitioning of glutamine synthesized by the human placenta between the maternal and fetal circulations. Placenta, (2013) 10. 003.
Day P, Matata B and Elahi M. Re-visiting glutamate toxicity:Implications of monosodium glutamate consumption on glutamate metabolism and metabolic syndrome.J. Endocrinol. Diabetes Mellit, (2015), in press.
Cleal JK, Day PE, Hanson MA, & Lewis RM (2009). Measurement of housekeeping genes in human placenta. Placenta 30, 1002-1003
Cleal JK, Day PE, Hanson MA, & Lewis RM (2010). Sex differences in the mRNA levels of housekeeping genes in human placenta. Placenta 31, 556-557
Cleal JK, Glazier J, Nain G, Crosier SR, Day PE, Harvey NC, Robinson SM, Cooper C, Godfrey KM, Hanson MA, & Lewis RM (2011). Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast. J Physiol, 589(4): 987-997