My research area is focused on brown adipose tissue (BAT) expansion and thermogenic activity in the context of obesity. Based on recent finding of active BAT in humans, promoting it expansion and activation is considered as a potential therapeutical target of obesity and associated complications. The expansion of BAT is driven its sustained activation by the sympathetic nervous system and the recruitment of progenitors, adequate vascularization and a permissive Extracellular Matrix (ECM). Influence of obesity and associated chronic inflammation on adipose tissue functions is well described in the context of white adipose tissue but remained poorly documented in BAT, particularly regarding it expansion capacity and thermogenic activity. Then, my general objective is to identify the cellular and molecular mechanisms involved in the dynamic of BAT expansion during obesity, particularly by focusing on cellular and tissular remodelling. Understanding mechanisms involved in BAT remodelling during obesity could highlight new molecular actors, constituting potential targets in BAT activation and expansion in order to limit obesity-induced lipotoxicity and associated morbidities.
1. Pellegrinelli V, Heuvingh J, du Roure O, Rouault C, Devulder A, Klein C, et al. Human adipocyte function is impacted by mechanical cues. J Pathol. 2014 Mar 12;
2. Pellegrinelli V, Rouault C, Veyrie N, Clément K, Lacasa D. Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions In A 3D Setting: Partial Rescue By Angiopoietin-1. Diabetes. 2013 Oct 15;
3. Rouault C, Pellegrinelli V, Schilch R, Cotillard A, Poitou C, Tordjman J, et al. Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue. Endocrinology. 2013 Mar;154(3):1069–79.
4. Mejhert N, Wilfling F, Esteve D, Galitzky J, Pellegrinelli V, Kolditz C-I, et al. Semaphorin 3C is a novel adipokine linked to extracellular matrix composition. Diabetologia. 2013 Aug;56(8):1792–801.
5. Reggio S, Pellegrinelli V, Clément K, Tordjman J. Fibrosis as a Cause or a Consequence of White Adipose Tissue Inflammation in Obesity. Current Obesity Reports. 2012 Dec 30;2(1):1–9.
6. Lacasa D, Pellegrinelli V, Keophiphath M, Clément K. Patent WO/2011/148310A1 Internet. cited 2012 Dec 29. Available from: http://www.sumobrain.com/patents/wipo/Method-culturing-adipocytes/WO2011148310A1.pdf