skip to primary navigation skip to content
Loading Events

« All Events

  • This event has passed.

Dr Alexander Galkin: “Characterisation of hypoxic conformational change of mitochondrial complex I”

3rd June 2015 @ 3:00 pm - 4:00 pm

Free
Wed, 3 June, 2015
3:00 pm
Lecture Theatre, Level 7
Host: Mike Murphy
Dr Alexander Galkin
Queen’s University, Belfast

Complex I or NADH:ubiquinone oxidoreductase is a key enzyme of respiration in eukaryotes. An interesting characteristic of complex I from mammals is the ability to adopt two conformationally distinct states: the so-called catalytically active (A) and the de-active, dormant state (D). The regulation of this enzyme is not completely understood and the mechanisms and driving force behind the A/D transition is currently unknown. The A/D transition could represent an intrinsic mechanism which provides a fast response of the mitochondrial respiratory chain to oxygen deprivation and modulation of the A/D equilibrium in situ could be a way to ameliorate the ischaemia/reperfusion damage.

Details

Date:
3rd June 2015
Time:
3:00 pm - 4:00 pm
Cost:
Free
Event Category:
Website:
http://www.mrc-mbu.cam.ac.uk/seminars

Organiser

MRC Mitochondrial Biology Unit
View Organiser Website

Venue

Lecture Theatre, Wellcome Trust/MRC Building Level 7
Addenbrooke’s Hospital
Cambridge, CB2 0XY
+ Google Map