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Dr Alexander Galkin: “Characterisation of hypoxic conformational change of mitochondrial complex I”

3rd June 2015 @ 3:00 pm - 4:00 pm

Wed, 3 June, 2015
3:00 pm
Lecture Theatre, Level 7
Host: Mike Murphy
Dr Alexander Galkin
Queen’s University, Belfast

Complex I or NADH:ubiquinone oxidoreductase is a key enzyme of respiration in eukaryotes. An interesting characteristic of complex I from mammals is the ability to adopt two conformationally distinct states: the so-called catalytically active (A) and the de-active, dormant state (D). The regulation of this enzyme is not completely understood and the mechanisms and driving force behind the A/D transition is currently unknown. The A/D transition could represent an intrinsic mechanism which provides a fast response of the mitochondrial respiratory chain to oxygen deprivation and modulation of the A/D equilibrium in situ could be a way to ameliorate the ischaemia/reperfusion damage.


3rd June 2015
3:00 pm - 4:00 pm
Event Category:


MRC Mitochondrial Biology Unit
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Lecture Theatre, Wellcome Trust/MRC Building Level 7
Addenbrooke’s Hospital
Cambridge, CB2 0XY
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