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Dr Jennifer Asimit: “A Bayesian approach to the overlap analysis of epidemiologically linked traits”

27th May 2015 @ 2:00 pm - 3:00 pm

Free

If you have a question about this talk, please contact dff21.

Diseases often co-occur in individuals more often than expected by chance, and this may be explained by shared underlying genetic aetiology. Current detection approaches rely on p-values of individual studies. However, differences in power between studies are not accounted for by p-values whereas Bayes’ factors (BFs) do, and may be approximated from summary statistics. We use simulation studies to compare the power of frequentist and Bayesian approaches to overlap analyses, and to decide on appropriate thresholds for comparison between the two methods. It is empirically illustrated that BFs have the advantage over p-values of a decreasing type I error rate as study size increases in single-disease associations. Consequently, the overlap analysis of traits from different-sized studies encounters issues in fair p-value threshold selection, while BFs are adjusted automatically. Extensive simulations show that Bayesian overlap analyses tend to have higher power than those that assess association strength with p-values, particularly in low power scenarios. An application of our methods is used to identify variants associated with both obesity and osteoarthritis.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

Cardiovascular Seminars take place on every other Thursday 1-2pm in the Clinical School, Addenbrooke’s site. Sandwich lunch including tea, coffee & cakes is provided 12.30pm outside the seminar room.

Details

Date:
27th May 2015
Time:
2:00 pm - 3:00 pm
Cost:
Free
Event Category:
Website:
http://talks.cam.ac.uk/talk/index/59209

Organiser

Cambridge Cardiovascular
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Venue

Thomas Strangeways Room, Strangeways Research Laboratory
2 Worts' Causeway
Cambridge, CB1 8RN United Kingdom
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