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Dr Sophie Trefely, Signalling and Epigenetics, The Babraham Institute, Cambridge – ‘Compartmentalised metabolism and metabolite signalling to the nucleus’

February 14 @ 1:15 pm - 2:15 pm

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EXTERNAL RESEARCH SEMINAR SERIES LENT 2023

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Speaker: Dr Sophie Trefely, Signalling and Epigenetics, The Babraham Institute, Cambridge

Title: Compartmentalised metabolism and metabolite signalling to the nucleus

 

Host: Dr Daniel Fazakerley, IMS-MRL

Time: 13.15

 

Abstract:

Intracellular metabolites act as powerful signalling cues to adjust cell behaviour to the nutrient environment. A variety of metabolites operate in the nucleus as substrates, co-factors, or inhibitors of chromatin-modifying enzymes and have emerged as key determinants of gene regulation. Given that cellular metabolism is highly compartmentalized, our understanding of pathways connecting nutrients to nuclear metabolites has been limited since standard metabolite analyses use whole cells. I will talk about my recent work on the development of novel approaches for sub-cellular metabolite analyses by mass spectrometry, with a focus on the acyl-Coenzyme A metabolite class. This work shows that the nucleus operates as a distinct metabolic compartment and marks an exciting step forward in understanding regulation of metabolism within the nucleus and how this links diet to the epigenome.

 

For members of Cambridge Metabolism wishing to join the online event, please contact Angela Lumsdon

Details

Date:
February 14
Time:
1:15 pm - 2:15 pm
Event Category: