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James Staley & James Blackshaw: “MR Catalogue – a database of human genotype-phenotype associations”
23rd February 2016 @ 1:00 pm - 2:00 pmFree
All welcome, no need to book
Mendelian Randomisation (MR) Catalogue is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate “phenome scans”, the cross-referencing of genetic variants with many phenotypes, to help aid understanding of disease pathways and biology as well as inform MR studies. The catalogue currently contains over 300 million association results and over 10 million unique genetic variants, mostly single nucleotide polymorphisms. It is accompanied by a web-based tool that queries the database for associations with user-specified variants, providing results aligned according to the alleles of each input variant. The tool provides the option of searching for trait associations with proxies of the input variants, calculated using the European samples from 1000 Genomes phase 3.
MR Catalogue is available at www.mrcatalogue.medschl.cam.ac.uk
Demonstration & Future Developments:
As part of the presentation, James S and James B will be demonstrating how to use the website and discussing the planned future developments of MR Catalogue. Any suggestions on future developments would be most welcome.