Wednesday 16 January
08:45 | **Registration opens** | |
09:30 | Patrick Maxwell, University of Cambridge | Welcome from the Regius Professor of Physic and Head of the School of Clinical Medicine |
09:40 |
Session 1: Epigenetic responses to metabolic / environmental changes |
|
Paolo Sassone-Corsi, University of California | The epigenetic language of circadian metabolism (KEYNOTE lecture) | |
Jane Mellor, Univeristy of Oxford | Deconstructing the relationship between metabolism, chromatin and gene expression in the yeast metabolic cycle | |
**Break and exhibition** | ||
Andrew Pospisilik, Van Andel Research institute and Max Planck Institute of Immunobiology and Epigenetics | Epigenetic contributions to metabolic disease heterogeneity | |
Marcus Buschbeck, Josep Carreras Leukaemia Research institute | Short talk: Histone variants link metabolism to 3D chromatin architecture | |
12:30 | Poster previews | |
12:45 | **Lunch, optional sessions and posters** | |
15:10 |
Session 2: Metabolic control of epigenetic pathways |
|
Wolfgang Fischle, KAUST | Lipid precursors and lipids in chromatin regulation | |
Kathryn Wellen, University of Pennsylvania | Acetyl-CoA metabolism and chromatin regulation | |
Mattia Zhaghi, Vita-Salute San Raffaele university | Short talk: SETD5, a new connection between epigenetic & mitochondrial function | |
**Break and exhibition** | ||
Thomas Carell, LMU | Title TBC | |
Andreas Ladurner. LMU | Allosteric activation of a chromatin remodelling oncogene by NAD metabolites | |
18:00 | Day 1 close | |
18:45 | Drinks reception and conference dinner at Selwyn College |
Thursday 17 January
09:05 | Session 3: Physiological effects on the epigenome | |
Erica Watson, University of Cambridge | How your grandparents’ sins affect your health | |
Marika Charalambous, KCL | Genomic Imprinting – adiposity and pregnancy | |
Alice Taylor, University of Cambridge | Short talk: Methionine metabolism impacts maintenance of AML with chromatin regulation | |
**Break and exhibition** | ||
Cecilia Lindgren, University of Oxford | Epigenomics of common obesity | |
Olivia Casaneueva, Babraham Institute | Variability in neuronal heat shock responses causes heterogeneity in fat metabolism across individual worms | |
Simona Pedrotti, San Raffaele Hospital | Short talk: The histone methyltransferases Suv420h regulate PPAR-γ and energy expenditure in response to environmental stimuli | |
12:00 | **Lunch and optional sessions** | |
13:25 | Session 4: Metabolism and epigenetics in disease | |
Judith Favier, INSERM | Uncoupled effects of TET inhibition and hypoxia in SDH-deficient cells | |
Sevin Turcan, National Centre for Tumor Diseases, Heidelberg | The impact of IDH1 mutation on the glioma epigenome | |
**Break and exhibition** | ||
Jason Locasale, Duke University | Diet, cancer and epigenetics | |
Brian Huntly, University of Cambridge | Transcriptional and metabolic alterations during leukaemia evolution | |
15:50 | Prof Sir Steve O’Rahilly, University of Cambridge Prizes and closing remarks | |
16:00 | Close |
In addition to our plenary sessions the conference will offer an excellent opportunity to meet scientists outside your usual area of study and to think more broadly about your research. As well as plenty of time allowed for networking, to browse our exhibition and see posters presented by other participants, the programme will offer extra opportunities including:
- ‘Meet the speaker’ tables – dedicated time for conversations, over lunch, with some of our speakers
- Research talk from Rab Prinjha, VP Head of Epigenetics DPU, GSK
- Alternatives to academia. Careers session with Rab Prinjha, VP Head of Epigenetics DPU, GSK. Marc van der Schee, Head of Clinical at Owlstone Medical Ltd. and Daniel Ives, CEO of early stage startup Shift Bioscience.
Registered participants will be invited to sign up for one or more of our optional sessions shortly before the conference.
Who will be there?
This open meeting will draw experts and researchers who are new to the field from areas of study that are currently separated: cellular metabolism and epigenetics. It will embrace both interactions between small molecular metabolites with chromatin modifiers and clinically-relevant studies, bringing together researchers working on cancer, metabolic disease, chromatin regulation and diet.
Early Career Researchers are welcomed and encouraged to submit abstracts (please indicate interest when you REGISTER).
Our sponsors