Dr Ioannis Kamzolas

My research focuses on understanding the molecular mechanisms that drive the progression of metabolic dysfunction-associated steatotic liver disease (MASLD/MASH). I develop computational approaches to reconstruct disease trajectories from large-scale transcriptomic and multi-omics datasets, with the aim of identifying the biological processes underlying disease progression and discovering biomarkers for diagnosis, patient stratification, and therapeutic intervention.

More broadly, I am interested in applying bioinformatics, machine learning, and integrative multi-omics approaches to study metabolic diseases. My work combines bulk and single-cell transcriptomics, spatial transcriptomics, network analysis, and systems biology to translate complex biological data into mechanistic insights. I also investigate adipose tissue biology and evaluate preclinical rodent models to improve their translational relevance to human disease.